Selective cargo sorting in stem cell‐derived small extracellular vesicles: impact on therapeutic efficacy for intervertebral disc degeneration

Selective cargo sorting in stem cell‐derived small extracellular vesicles: impact on therapeutic efficacy for intervertebral disc degeneration

Abstract Background Growing evidence has suggested the role of stem cell‐derived small extracellular vesicles (sEVs) in intervertebral disc degeneration (IVDD). The cargo sorting of sEVs, particularly miRNAs, may be influenced when the donor cell is subjected to oxidative stress. Here, we discovered...

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Bibliographic Details
Main Authors: Zhiwei Liao, Bide Tong, Xiaoguang Zhang, Weifeng Zhang, Wencan Ke, Huaizhen Liang, Ming Lei, Wenbin Hua, Shuai Li, Yu Song, Xinghuo Wu, Cao Yang
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Clinical and Translational Medicine
Subjects:
extracellular vesicles
ferroptosis
intervertebral disc regeneration
miRNA sorting
oxidative stress
Online Access:https://doi.org/10.1002/ctm2.1494

Internet

https://doi.org/10.1002/ctm2.1494

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