Transcriptional profiling of human cartilage endplate cells identifies novel genes and cell clusters underlying degenerated and non-degenerated phenotypes

Transcriptional profiling of human cartilage endplate cells identifies novel genes and cell clusters underlying degenerated and non-degenerated phenotypes

Abstract Background Low back pain is a leading cause of disability worldwide and is frequently attributed to intervertebral disc (IVD) degeneration. Though the contributions of the adjacent cartilage endplates (CEP) to IVD degeneration are well documented, the phenotype and functions of the resident...

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Bibliographic Details
Main Authors: Kyle Kuchynsky, Patrick Stevens, Amy Hite, William Xie, Khady Diop, Shirley Tang, Maciej Pietrzak, Safdar Khan, Benjamin Walter, Devina Purmessur
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Arthritis Research & Therapy
Subjects:
Cartilage endplate
Intervertebral disc
Human
Degeneration
Bulk RNA-Seq
Single-cell RNA-Seq
Online Access:https://doi.org/10.1186/s13075-023-03220-6

Internet

https://doi.org/10.1186/s13075-023-03220-6

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