Identifying a distinct fibrosis subset of NAFLD via molecular profiling and the involvement of profibrotic macrophages

Identifying a distinct fibrosis subset of NAFLD via molecular profiling and the involvement of profibrotic macrophages

Abstract Background There are emerging studies suggesting that non-alcoholic fatty liver disease (NAFLD) is a heterogeneous disease with multiple etiologies and molecular phenotypes. Fibrosis is the key process in NAFLD progression. In this study, we aimed to explore molecular phenotypes of NAFLD wi...

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Bibliographic Details
Main Authors: Weiwei He, Yinxiang Huang, Xiulin Shi, Qingxuan Wang, Menghua Wu, Han Li, Qiuhong Liu, Xiaofang Zhang, Caoxin Huang, Xuejun Li
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Translational Medicine
Subjects:
Non-alcoholic fatty liver disease
Fibrosis subtype
Transcriptomic signatures
Non-negative matrix factorization
Profibrotic macrophages
Online Access:https://doi.org/10.1186/s12967-023-04300-6

Internet

https://doi.org/10.1186/s12967-023-04300-6

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