Conformational pathway provides unique sensitivity to a synaptic mGluR

Conformational pathway provides unique sensitivity to a synaptic mGluR

Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutamate response of an mGluR.

Bibliographic Details
Main Authors: Chris H. Habrian, Joshua Levitz, Vojtech Vyklicky, Zhu Fu, Adam Hoagland, Isabelle McCort-Tranchepain, Francine Acher, Ehud Y. Isacoff
Format: Article
Language:English
Published: Nature Portfolio 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13407-8

Internet

https://doi.org/10.1038/s41467-019-13407-8

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