Conformational pathway provides unique sensitivity to a synaptic mGluR
Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutamate response of an mGluR.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13407-8 |
| _version_ | 1818433727586369536 |
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| author | Chris H. Habrian Joshua Levitz Vojtech Vyklicky Zhu Fu Adam Hoagland Isabelle McCort-Tranchepain Francine Acher Ehud Y. Isacoff |
| author_facet | Chris H. Habrian Joshua Levitz Vojtech Vyklicky Zhu Fu Adam Hoagland Isabelle McCort-Tranchepain Francine Acher Ehud Y. Isacoff |
| author_sort | Chris H. Habrian |
| collection | DOAJ |
| description | Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutamate response of an mGluR. |
| first_indexed | 2024-12-14T16:25:42Z |
| format | Article |
| id | doaj.art-118cbbd567084baca674e6ab3894b693 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:25:42Z |
| publishDate | 2019-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-118cbbd567084baca674e6ab3894b6932022-12-21T22:54:42ZengNature PortfolioNature Communications2041-17232019-12-0110111310.1038/s41467-019-13407-8Conformational pathway provides unique sensitivity to a synaptic mGluRChris H. Habrian0Joshua Levitz1Vojtech Vyklicky2Zhu Fu3Adam Hoagland4Isabelle McCort-Tranchepain5Francine Acher6Ehud Y. Isacoff7Biophysics Graduate Group, University of CaliforniaDepartment of Molecular and Cell Biology, University of CaliforniaDepartment of Molecular and Cell Biology, University of CaliforniaDepartment of Molecular and Cell Biology, University of CaliforniaDepartment of Molecular and Cell Biology, University of CaliforniaParis Descartes UniversityParis Descartes UniversityBiophysics Graduate Group, University of CaliforniaMetabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutamate response of an mGluR.https://doi.org/10.1038/s41467-019-13407-8 |
| spellingShingle | Chris H. Habrian Joshua Levitz Vojtech Vyklicky Zhu Fu Adam Hoagland Isabelle McCort-Tranchepain Francine Acher Ehud Y. Isacoff Conformational pathway provides unique sensitivity to a synaptic mGluR Nature Communications |
| title | Conformational pathway provides unique sensitivity to a synaptic mGluR |
| title_full | Conformational pathway provides unique sensitivity to a synaptic mGluR |
| title_fullStr | Conformational pathway provides unique sensitivity to a synaptic mGluR |
| title_full_unstemmed | Conformational pathway provides unique sensitivity to a synaptic mGluR |
| title_short | Conformational pathway provides unique sensitivity to a synaptic mGluR |
| title_sort | conformational pathway provides unique sensitivity to a synaptic mglur |
| url | https://doi.org/10.1038/s41467-019-13407-8 |
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