Vital Roles of Gremlin‐1 in Pulmonary Arterial Hypertension Induced by Systemic‐to‐Pulmonary Shunts

Vital Roles of Gremlin‐1 in Pulmonary Arterial Hypertension Induced by Systemic‐to‐Pulmonary Shunts

Background Heterozygous mutation in BMP (bone morphogenetic protein) receptor 2 is rare, but BMP cascade suppression is common in congenital heart disease–associated pulmonary arterial hypertension (CHD‐PAH); however, the underling mechanism of BMP cascade suppression independent of BMP receptor 2 m...

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Bibliographic Details
Main Authors: Liukun Meng, Xiao Teng, Yao Liu, Chao Yang, Shengwei Wang, Wen Yuan, Jian Meng, Hongjie Chi, Lihua Duan, Xiaoyan Liu
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
BMP cascade
congenital heart disease
gremlin‐1
pulmonary artery hypertension
systemic‐to‐pulmonary shunt
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.016586

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.016586

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