Sustained activation of EGFR-ERK1/2 signaling limits the response to tigecycline-induced mitochondrial respiratory deficiency in liver cancerResearch in context

Sustained activation of EGFR-ERK1/2 signaling limits the response to tigecycline-induced mitochondrial respiratory deficiency in liver cancerResearch in context

Summary: Background: Identification of tumor dependencies is important for developing therapeutic strategies for liver cancer. Methods: A genome-wide CRISPR screen was performed for finding critical vulnerabilities in liver cancer cells. Compounds screen, RNA sequencing, and human phospho-receptor...

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Main Authors: Yangyang Zhou, Siying Wang, Wei Wu, Jing Ling, Haoyu Li, Qi Jia, Jiaojiao Zheng, Xingling Zheng, Ruobing Yu, Qiangxin Wu, Yaoping Shi, Cor Lieftink, Roderick L. Beijersbergen, Shengxian Yuan, René Bernards, Haojie Jin, Wenxin Qin
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:EBioMedicine
Subjects:
CRISPR screen
Tigecycline
MEK
Glycolysis
Oxidative phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422005795

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http://www.sciencedirect.com/science/article/pii/S2352396422005795

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