Basic mechanisms of platelet receptor shedding

Proteolytic shedding of the extracellular ectodomain of platelet receptors provides a key mechanism for irreversible loss of ligand-binding capacity, and for regulating platelet function in health and disease. Platelets derived from megakaryocytes are small anucleate cells in peripheral blood, with...

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Bibliographic Details
Main Authors: Robert K. Andrews, Elizabeth E. Gardiner
Format: Article
Language:English
Published: Taylor & Francis Group 2017-05-01
Series:Platelets
Subjects:
Online Access:http://dx.doi.org/10.1080/09537104.2016.1235690