Lentivirus-Mediated Silencing of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 Inhibits Release of Inflammatory Cytokines and Apoptosis in Renal Tubular Epithelial Cells Via Inhibition of the TLR4/NF-kB Pathway in Renal Ischemia-Reperfusion Injury

Lentivirus-Mediated Silencing of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 Inhibits Release of Inflammatory Cytokines and Apoptosis in Renal Tubular Epithelial Cells Via Inhibition of the TLR4/NF-kB Pathway in Renal Ischemia-Reperfusion Injury

Background/Aims: Renal reperfusion injury occurs after the blood flow to the ischemic kidney is re-established under various clinical conditions, such as organ transplantation, renal artery stenosis, embolic disease, and the repair of descending aortic. The current study aims to explore the effects...

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Bibliographic Details
Main Authors: Jing-Fei Teng, Kai Wang, Zhuo-Min Jia, Yan-Jie Guo, Ya-Wei Guan, Zhi-Hui Li, Xing Ai
Format: Article
Language:English
Published: Karger Publishers 2018-07-01
Series:Kidney & Blood Pressure Research
Subjects:
Shp-2
TLR4/NF-κB signaling pathway
Renal ischemia-reperfusion injury
Renal tubular epithelial cell
Inflammatory cytokine
Apoptosis
Online Access:https://www.karger.com/Article/FullText/491565

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https://www.karger.com/Article/FullText/491565

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