Fingolimod (FTY720) Preserves High Energy Phosphates and Improves Cardiac Function in Heterotopic Heart Transplantation Model

Fingolimod (FTY720) Preserves High Energy Phosphates and Improves Cardiac Function in Heterotopic Heart Transplantation Model

During heart transplantation, donor heart leads to reduced oxygen supply resulting in low level of high energy phosphate (HEP) reserves in cardiomyocyte. Lower HEP is one of the underlying reasons of cell death due to ischemia. In this study we investigated the role of Fingolimod (FTY720) in heart t...

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Bibliographic Details
Main Authors: Naseer Ahmed, Javeria Farooq, Soban Sadiq, Sultan Ayoub Meo, Azam Jan, Faisal H. Cheema, Giuseppe Faggian, Alessio Rungatscher
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
fingolimod (FTY720)
cardiac function
coronary blood flow
high energy phosphates
poly (ADP ribose) polymerase
Online Access:https://www.mdpi.com/1422-0067/21/18/6548

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https://www.mdpi.com/1422-0067/21/18/6548

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