Co-formulation of the rF1V plague vaccine with depot-formulated cytokines enhances immunogenicity and efficacy to elicit protective responses against aerosol challenge in mice

Co-formulation of the rF1V plague vaccine with depot-formulated cytokines enhances immunogenicity and efficacy to elicit protective responses against aerosol challenge in mice

This study evaluated a depot-formulated cytokine-based adjuvant to improve the efficacy of the recombinant F1V (rF1V) plague vaccine and examined the protective response following aerosol challenge in a murine model. The results of this study showed that co-formulation of the Alhydrogel-adsorbed rF1...

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Bibliographic Details
Main Authors: Darrell R. Galloway, Jiahui Li, Nguyen X. Nguyen, Frank W. Falkenberg, Lisa Henning, Robert Krile, Ying-Liang Chou, James N. Herron, J. Scott Hale, E. Diane Williamson
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
vaccination
plague vaccine
cytokine depot adjuvant
Yersinia pestis
subunit vaccine
co-immunization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1277526/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1277526/full

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