Elevated Levels of Peripheral Kynurenine Decrease Bone Strength in Rats with Chronic Kidney Disease

Elevated Levels of Peripheral Kynurenine Decrease Bone Strength in Rats with Chronic Kidney Disease

The diagnosis and treatment of bone disorders in patients with chronic kidney disease (CKD) represent a clinical challenge. CKD leads to mineral and bone complications starting early in the course of renal failure. Recently, we have observed the positive relationship between intensified central kynu...

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Bibliographic Details
Main Authors: Bartlomiej Kalaska, Krystyna Pawlak, Tomasz Domaniewski, Ewa Oksztulska-Kolanek, Beata Znorko, Alicja Roszczenko, Joanna Rogalska, Malgorzata M. Brzoska, Pawel Lipowicz, Michal Doroszko, Anna Pryczynicz, Dariusz Pawlak
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Physiology
Subjects:
chronic kidney disease
bone disorders
tryptophan metabolites
kynurenine pathway
aryl hydrocarbon receptor
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00836/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00836/full

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