Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain

Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain

We have exploited whole brain microscopy to map the progressive deposition of hyperphosphorylated tau in intact, cleared mouse brain. We found that the three-dimensional spreading pattern of hyperphosphorylated tau in the brain of an aging Tau.P301L mouse model did not resemble that observed in AD p...

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Bibliographic Details
Main Authors: Jan R. Detrez, Hervé Maurin, Kristof Van Kolen, Roland Willems, Julien Colombelli, Benoit Lechat, Bart Roucourt, Fred Van Leuven, Sarah Baatout, Peter Larsen, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Hyperphosphorylated tau
Tau
Alzheimer's disease
Tau.P301L
Whole brain imaging
Light-sheet microscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611930066X

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http://www.sciencedirect.com/science/article/pii/S096999611930066X

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