Enrichment of miR-17-5p enhances the protective effects of EPC-EXs on vascular and skeletal muscle injury in a diabetic hind limb ischemia model

Enrichment of miR-17-5p enhances the protective effects of EPC-EXs on vascular and skeletal muscle injury in a diabetic hind limb ischemia model

Abstract Background/aims Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection. Endothelial progenitor cell (EPC)-released exosomes (EPC-EXs) contribute to vascular protection and isc...

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Bibliographic Details
Main Authors: Qunwen Pan, Xiaobing Xu, Wen He, Yan Wang, Zhi Xiang, Xiaojuan Jin, Qiong Tang, Ting Zhao, Xiaotang Ma
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Biological Research
Subjects:
Diabetic hind limb ischemia
Endothelial progenitor cells
Exosomes
miR-17-5p
Online Access:https://doi.org/10.1186/s40659-023-00418-5

Internet

https://doi.org/10.1186/s40659-023-00418-5

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