Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure

Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure

Correct fetal testis development underpins adult male fertility, and TGFβ superfamily ligands control key aspects of this process. Transcripts encoding one such ligand, activin A, are upregulated in testes after sex determination and remain high until after birth. Testis development requires activin...

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Bibliographic Details
Main Authors: Penny A. F. Whiley, Michael C. M. Luu, Liza O’Donnell, David J. Handelsman, Kate L. Loveland
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Endocrinology
Subjects:
spermatogenesis
gonocyte
testicular dysgenesis
MEHP
phthalate
multinucleated germ cell
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1234712/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1234712/full

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