Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure
Correct fetal testis development underpins adult male fertility, and TGFβ superfamily ligands control key aspects of this process. Transcripts encoding one such ligand, activin A, are upregulated in testes after sex determination and remain high until after birth. Testis development requires activin...
Main Authors: | Penny A. F. Whiley, Michael C. M. Luu, Liza O’Donnell, David J. Handelsman, Kate L. Loveland |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-09-01
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Series: | Frontiers in Endocrinology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1234712/full |
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