Bcl-2 and N-Myc Coexpression Increases IGF-IR and Features of Malignant Growth in Neuroblastoma Cell Lines

Bcl-2 and N-Myc Coexpression Increases IGF-IR and Features of Malignant Growth in Neuroblastoma Cell Lines

The bcl-2 and c-myc oncogenes cooperate to transform multiple cell types. In the pediatric malignancy NB2, Bcl2 is highly expressed. In tumors with a poor prognosis, N-Myc, a protein homologous to c-Myc, is overexpressed as a result of gene amplification. The present study was designed to determine...

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Bibliographic Details
Main Authors: Rama Jasty, Cynthia {ptvan} Golen, Huey-Jen Lin, Gabe Solomon, Kathleen Heidelberger, Peter Polverini, Anthony Opipari, Eva Feldman, Valerie P. Castle
Format: Article
Language:English
Published: Elsevier 2001-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
neuroblastoma
apoptosis
angiogenesis
tumorigenicity
N-Myc
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558601800336

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http://www.sciencedirect.com/science/article/pii/S1476558601800336

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