Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

Abstract Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via lysosomal proteolysis. Here we report that defective cystine mobilization from ly...

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Bibliographic Details
Main Authors: Marine Berquez, Zhiyong Chen, Beatrice Paola Festa, Patrick Krohn, Svenja Aline Keller, Silvia Parolo, Mikhail Korzinkin, Anna Gaponova, Endre Laczko, Enrico Domenici, Olivier Devuyst, Alessandro Luciani
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39261-3

Internet

https://doi.org/10.1038/s41467-023-39261-3

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