The relationships between cholesterol crystals, NLRP3 inflammasome, and coronary atherosclerotic plaque vulnerability in acute coronary syndrome: An optical coherence tomography study

The relationships between cholesterol crystals, NLRP3 inflammasome, and coronary atherosclerotic plaque vulnerability in acute coronary syndrome: An optical coherence tomography study

BackgroundCholesterol crystals (CCs) in lesions are the hallmark of advanced atherosclerotic plaque. Previous studies have demonstrated that CCs could activate NLRP3 inflammasome, which played an important role in atherosclerotic lesion progression. However, the relationship between CCs, NLRP3 infla...

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Bibliographic Details
Main Authors: Chao Xue, Qizhi Chen, Ling Bian, Zhaofang Yin, Zuojun Xu, Huili Zhang, Qingyong Zhang, Junfeng Zhang, Changqian Wang, Run Du, Li Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
acute coronary syndrome
cholesterol crystals
NLRP3 inflammasome
interleukin (IL)-1β
IL-18
optical coherence tomography
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.905363/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.905363/full

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