Enriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection

Enriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection

Trained immunity is an innate immune memory response that is induced by a primary inflammatory stimulus that sensitizes monocytes and macrophages to a secondary pathogenic challenge, reprogramming the host response to infection and inflammatory disease. Dietary fatty acids can act as inflammatory st...

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Bibliographic Details
Main Authors: Amy L Seufert, James W Hickman, Ste K Traxler, Rachael M Peterson, Trent A Waugh, Sydney J Lashley, Natalia Shulzhenko, Ruth J Napier, Brooke A Napier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
trained immunity
innate immune memory
macrophages
inflammation
palmitic acid
ceramide
Online Access:https://elifesciences.org/articles/76744

Internet

https://elifesciences.org/articles/76744

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