PUMILIO hyperactivity drives premature aging of Norad-deficient mice

PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here, we investigated the physiologic function of the conserved lncRNA Norad in vivo. Deletion of Norad in mice results in genomic instability and mitochond...

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Bibliographic Details
Main Authors: Florian Kopp, Mahmoud M Elguindy, Mehmet E Yalvac, He Zhang, Beibei Chen, Frank A Gillett, Sungyul Lee, Sushama Sivakumar, Hongtao Yu, Yang Xie, Prashant Mishra, Zarife Sahenk, Joshua T Mendell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
long noncoding RNA
aging
Norad
PUMILIO
genomic stability
mitochondria
Online Access:https://elifesciences.org/articles/42650

Internet

https://elifesciences.org/articles/42650

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