Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression

Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression

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Summary: Embryonic expression of DNMT3B is critical for establishing de novo DNA methylation. This study uncovers the mechanism through which the promoter-associated long non-coding RNA (lncRNA) Dnmt3bas controls the induction and alternative splicing of Dnmt3b during embryonic stem cell (ESC) diffe...

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Bibliographic Details
Main Authors: Mohd Saleem Dar, Isaiah K. Mensah, Ming He, Sarah McGovern, Ikjot Singh Sohal, Hannah Christian Whitlock, Nina Elise Bippus, Madison Ceminsky, Martin L. Emerson, Hern J. Tan, Mark C. Hall, Humaira Gowher
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723005983

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http://www.sciencedirect.com/science/article/pii/S2211124723005983

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