Engineering PTEN-L for Cell-Mediated Delivery

Engineering PTEN-L for Cell-Mediated Delivery

The tumor suppressor PTEN is frequently inactivated in glioblastoma. PTEN-L is a long form of PTEN produced by translation from an alternate upstream start codon. Unlike PTEN, PTEN-L has a signal sequence and a tract of six arginine residues that allow PTEN-L to be secreted from cells and be taken u...

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Bibliographic Details
Main Authors: Sylvie J. Lavictoire, Alexander Gont, Lisa M. Julian, William L. Stanford, Caitlyn Vlasschaert, Douglas A. Gray, Danny Jomaa, Ian A.J. Lorimer
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117301225

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http://www.sciencedirect.com/science/article/pii/S2329050117301225

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