A <i>CNTNAP1</i> Missense Variant Is Associated with Canine Laryngeal Paralysis and Polyneuropathy

A <i>CNTNAP1</i> Missense Variant Is Associated with Canine Laryngeal Paralysis and Polyneuropathy

Laryngeal paralysis associated with a generalized polyneuropathy (LPPN) most commonly exists in geriatric dogs from a variety of large and giant breeds. The purpose of this study was to discover the underlying genetic and molecular mechanisms in a younger-onset form of this neurodegenerative disease...

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Bibliographic Details
Main Authors: Anna Letko, Katie M. Minor, Steven G. Friedenberg, G. Diane Shelton, Jill Pesayco Salvador, Paul J. J. Mandigers, Peter A. J. Leegwater, Paige A. Winkler, Simon M. Petersen-Jones, Bryden J. Stanley, Kari J. Ekenstedt, Gary S. Johnson, Liz Hansen, Vidhya Jagannathan, James R. Mickelson, Cord Drögemüller
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Genes
Subjects:
<i>Canis familiaris</i>
whole-genome sequencing
rare disease
contactin
neurological disorder
Leonberger
Online Access:https://www.mdpi.com/2073-4425/11/12/1426

Internet

https://www.mdpi.com/2073-4425/11/12/1426

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