A novel extracellular vesicles production system harnessing matrix homeostasis and macrophage reprogramming mitigates osteoarthritis

A novel extracellular vesicles production system harnessing matrix homeostasis and macrophage reprogramming mitigates osteoarthritis

Abstract Osteoarthritis (OA) is a degenerative disease that significantly impairs quality of life. There is a pressing need for innovative OA therapies. While small extracellular vesicles (sEVs) show promising therapeutic effects against OA, their limited yield restricts clinical translation. Here,...

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Bibliographic Details
Main Authors: Tianqi Wang, Hongqi Zhao, Yi Zhang, Yanshi Liu, Jialin Liu, Ge Chen, Ke Duan, Zhong Li, Hoi Po James Hui, Jiyuan Yan
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Nanobiotechnology
Subjects:
Extracellular vesicles
Electromagnetic field
Matrix homeostasis
Macrophage
Reprogramming
Osteoarthritis
Online Access:https://doi.org/10.1186/s12951-024-02324-8

Internet

https://doi.org/10.1186/s12951-024-02324-8

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