PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer’s Disease

PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer’s Disease

The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) involvement in Alzheimer’s disease (AD) is poorly investigated. We evaluated the in vitro PCSK9 modulation of astrocyte cholesterol metabolism and neuronal cholesterol supplying, which is fundamental for neuronal functions. Moreover, we inves...

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Bibliographic Details
Main Authors: Bianca Papotti, Maria Pia Adorni, Cinzia Marchi, Francesca Zimetti, Nicoletta Ronda, Giovanni Panighel, Maria Giovanna Lupo, Antonietta Vilella, Daniela Giuliani, Nicola Ferri, Franco Bernini
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
PCSK9
cholesterol
brain
astrocyte
neuron
apolipoprotein E
Online Access:https://www.mdpi.com/1422-0067/23/20/12192

Internet

https://www.mdpi.com/1422-0067/23/20/12192

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