Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy

Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy

To develop safer retroviral murine leukemia virus (MLV)-based vectors, we previously mutated and re-engineered the MLV integrase: the W390A mutation abolished the interaction with its cellular tethering factors, BET proteins, and a retargeting peptide (the chromodomain of the CBX1 protein) was fused...

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Bibliographic Details
Main Authors: Dominique Van Looveren, Giorgia Giacomazzi, Irina Thiry, Maurilio Sampaolesi, Rik Gijsbers
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
gene therapy
retroviral vectors
retargeted integration
insertional mutagenesis
mesoangioblast model
safer viral vectors
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001200

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http://www.sciencedirect.com/science/article/pii/S2329050121001200

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