Puerarin alleviates cadmium-induced rat neurocyte injury by alleviating Nrf2-mediated oxidative stress and inhibiting mitochondrial unfolded protein response

Puerarin alleviates cadmium-induced rat neurocyte injury by alleviating Nrf2-mediated oxidative stress and inhibiting mitochondrial unfolded protein response

Cadmium (Cd) is a highly neurotoxic environmental pollutant. Puerarin (Pur) is a natural antioxidant isolated from Kudzu root that exhibits a powerful neuroprotective effect. Herein, we illustrated the mechanism underlying the protective effect of Pur on Cd-induced rat neurocyte injury in an in vivo...

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Bibliographic Details
Main Authors: Wenhua Zhang, Mingchang Xu, Shuangquan Wen, Li Wang, Kanglei Zhang, Chaofan Zhang, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Puerarin
Cadmium
Neurotoxicity
Oxidative stress
Nrf2 signaling pathway
Mitochondrial unfolded protein response
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132201079X

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http://www.sciencedirect.com/science/article/pii/S014765132201079X

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