PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival

PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival

Human T-cell leukemia virus type-1 (HTLV-1) is a tumorigenic retrovirus responsible for development of adult T-cell leukemia/lymphoma (ATLL). This disease manifests after a long clinical latency period of up to 2–3 decades. Two viral gene products, Tax and HBZ, have transforming properties and play...

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Bibliographic Details
Main Authors: Amanda R. Panfil, Jacob Al-Saleem, Cory M. Howard, Jessica M. Mates, Jesse J. Kwiek, Robert A. Baiocchi, Patrick L. Green
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Viruses
Subjects:
HTLV-1
PRMT5
transformation
ATLL
Tax
HBZ
p30
lymphoma
Online Access:http://www.mdpi.com/1999-4915/8/1/7

Internet

http://www.mdpi.com/1999-4915/8/1/7

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