Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm

Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm

BackgroundThe prognosis of MYCN positive NB is poor, and there is no targeted drug for N-myc at present. This study aims to screen out hub genes closely related to MYCN, analyze the relationship between hub genes and NB microenvironment, and provide basis for molecular targeted therapy of MYCN posit...

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Bibliographic Details
Main Authors: Ji Chen, Mengjiao Sun, Chuqin Chen, Bin Jiang, Yongjun Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
MYCN
neuroblastoma
WGCNA
LASSO
tumor microenvironment
immune cell infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1016683/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1016683/full

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