Transglycosylation Activity of Engineered <i>Bifidobacterium</i> Lacto-<i>N</i>-Biosidase Mutants at Donor Subsites for Lacto-<i>N</i>-Tetraose Synthesis

Transglycosylation Activity of Engineered <i>Bifidobacterium</i> Lacto-<i>N</i>-Biosidase Mutants at Donor Subsites for Lacto-<i>N</i>-Tetraose Synthesis

The health benefits of human milk oligosaccharides (HMOs) make them attractive targets as supplements for infant formula milks. However, HMO synthesis is still challenging and only two HMOs have been marketed. Engineering glycoside hydrolases into transglycosylases may provide biocatalytic routes to...

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Bibliographic Details
Main Authors: Mireia Castejón-Vilatersana, Magda Faijes, Antoni Planas
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Bifidobacterium</i>
biocatalysis
human milk oligosaccharides
lacto-<i>N</i>-biosidase
protein engineering
transglycosylation
Online Access:https://www.mdpi.com/1422-0067/22/6/3230

Internet

https://www.mdpi.com/1422-0067/22/6/3230

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