Characterization of a novel potency endpoint for the evaluation of immune checkpoint blockade in humanized mice

IntroductionHumanized mice are emerging as valuable models to experimentally evaluate the impact of different immunotherapeutics on the human immune system. These immunodeficient mice are engrafted with human cells or tissues, that then mimic the human immune system, offering an alternative and pote...

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Bibliographic Details
Main Authors: Alba Matas-Céspedes, Jean-Martin Lapointe, Matthew J. Elder, Gareth J. Browne, Simon J. Dovedi, Lolke de Haan, Shaun Maguire, Richard Stebbings
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107848/full