Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors

Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors

The pyrimidine nucleus is a versatile core in the development of antiretroviral agents. On this basis, a series of pyrimidine-2,4-diones linked to an isoxazolidine nucleus have been synthesized and tested as nucleoside analogs, endowed with potential anti-HIV (human immunodeficiency virus) activity....

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Bibliographic Details
Main Authors: Roberto Romeo, Daniela Iannazzo, Lucia Veltri, Bartolo Gabriele, Beatrice Macchi, Caterina Frezza, Francesca Marino-Merlo, Salvatore V. Giofrè
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
reverse nucleosides
Pyrimidine-2,4-dione derivatives
HIV RT inhibitors
biological activity
molecular docking
Online Access:https://www.mdpi.com/1420-3049/24/9/1718

Internet

https://www.mdpi.com/1420-3049/24/9/1718

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