CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival

CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival

Abstract Despite multidisciplinary local and systemic therapeutic approaches, the prognosis for most patients with brain metastases is still dismal. The role of adaptive and innate anti-tumor response including the Human Leukocyte Antigen (HLA) machinery of antigen presentation is still unclear. We...

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Bibliographic Details
Main Authors: P. S. Zeiner, J. Zinke, D. J. Kowalewski, S. Bernatz, J. Tichy, M. W. Ronellenfitsch, F. Thorsen, A. Berger, M. T. Forster, A. Muller, J. P. Steinbach, R. Beschorner, J. Wischhusen, H. M. Kvasnicka, K. H. Plate, S. Stefanović, B. Weide, M. Mittelbronn, P. N. Harter
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Acta Neuropathologica Communications
Subjects:
CD74
HLA class II
Brain metastasis
HLA peptidome
Tumor infiltrating lymphocytes
Online Access:http://link.springer.com/article/10.1186/s40478-018-0521-5

Internet

http://link.springer.com/article/10.1186/s40478-018-0521-5

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