Myocardial Afterload Is a Key Biomechanical Regulator of Atrioventricular Myocyte Differentiation in Zebrafish

Myocardial Afterload Is a Key Biomechanical Regulator of Atrioventricular Myocyte Differentiation in Zebrafish

Heart valve development is governed by both genetic and biomechanical inputs. Prior work has demonstrated that oscillating shear stress associated with blood flow is required for normal atrioventricular (AV) valve development. Cardiac afterload is defined as the pressure the ventricle must overcome...

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Bibliographic Details
Main Authors: Neha Ahuja, Paige Ostwald, Alex Gendernalik, Elena Guzzolino, Letizia Pitto, David Bark, Deborah M. Garrity
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
developmental biology
hemodynamics
afterload
heart
biomechanics
valve
Online Access:https://www.mdpi.com/2308-3425/9/1/22

Internet

https://www.mdpi.com/2308-3425/9/1/22

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