Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos

Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos

Summary: Early embryogenesis depends on proper control of intracellular homeostasis of ions including Ca2+ and Mg2+. Deletion of the Ca2+ and Mg2+ conducting the TRPM7 channel is embryonically lethal in mice but leaves compaction, blastomere polarization, blastocoel formation, and correct specificat...

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Bibliographic Details
Main Authors: Aline Schütz, Christin Richter, Petra Weissgerber, Volodymyr Tsvilovskyy, Michael Hesse, Roger Ottenheijm, Frank Zimmermann, Stefanie Buchholz, Rebekka Medert, Sascha Dlugosz, Vladimir Kuryshev, Vladimir Benes, Veit Flockerzi, Bernd K. Fleischmann, Adolfo Cavalié, Marc Freichel
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
embryonic stem cells
TRPM7
developmental failure
trophectoderm
calcium
magnesium
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013188

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http://www.sciencedirect.com/science/article/pii/S2211124721013188

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