APOE ε4 carriage associates with improved myocardial performance from adolescence to older age

APOE ε4 carriage associates with improved myocardial performance from adolescence to older age

Abstract Background Although APOE ε4 allele carriage confers a risk for coronary artery disease, its persistence in humans might be explained by certain survival advantages (antagonistic pleiotropy). Methods Combining data from ~ 37,000 persons from three older age British cohorts (1946 National Sur...

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Bibliographic Details
Main Authors: Constantin-Cristian Topriceanu, Mit Shah, Matthew Webber, Fiona Chan, Hunain Shiwani, Marcus Richards, Jonathan Schott, Nishi Chaturvedi, James C. Moon, Alun D. Hughes, Aroon D. Hingorani, Declan P. O’Regan, Gabriella Captur
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Cardiovascular Disorders
Subjects:
Apolipoprotein ε4
Cardiovascular disease
Myocardial contraction fraction
Online Access:https://doi.org/10.1186/s12872-024-03808-z

Internet

https://doi.org/10.1186/s12872-024-03808-z

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