Spatial Transcriptomic Analysis of Focal and Normal Areas of Myocyte Disarray in Human Hypertrophic Cardiomyopathy

Spatial Transcriptomic Analysis of Focal and Normal Areas of Myocyte Disarray in Human Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy (HCM) is a common inherited disorder that can lead to heart failure and sudden cardiac death, characterized at the histological level by focal areas of myocyte disarray, hypertrophy and fibrosis, and only a few disease-targeted therapies exist. To identify the focal and s...

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Bibliographic Details
Main Authors: Jason Laird, Gayani Perera, Rebecca Batorsky, Hongjie Wang, Knarik Arkun, Michael T. Chin
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
hypertrophic cardiomyopathy
spatial transcriptomics
single-nucleus RNA sequencing
gene expression
bioinformatics
cardiovascular disorder
Online Access:https://www.mdpi.com/1422-0067/24/16/12625

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https://www.mdpi.com/1422-0067/24/16/12625

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