Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide

Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide

Abstract Cytotoxic-T-lymphocyte (CTL) mediated control of HIV-1 is enhanced by targeting highly networked epitopes in complex with human-leukocyte-antigen-class-I (HLA-I). However, the extent to which the presenting HLA allele contributes to this process is unknown. Here we examine the CTL response...

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Bibliographic Details
Main Authors: Xiaolong Li, Nishant Kumar Singh, David R. Collins, Robert Ng, Angela Zhang, Pedro A. Lamothe-Molina, Peter Shahinian, Shutong Xu, Kemin Tan, Alicja Piechocka-Trocha, Jonathan M. Urbach, Jeffrey K. Weber, Gaurav D. Gaiha, Overbeck Christian Takou Mbah, Tien Huynh, Sophia Cheever, James Chen, Michael Birnbaum, Ruhong Zhou, Bruce D. Walker, Jia-huai Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38573-8

Internet

https://doi.org/10.1038/s41467-023-38573-8

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