Berberine increases stromal production of Wnt molecules and activates Lgr5+ stem cells to promote epithelial restitution in experimental colitis

Berberine increases stromal production of Wnt molecules and activates Lgr5+ stem cells to promote epithelial restitution in experimental colitis

Abstract Background Inflammatory bowel diseases (IBDs) are characterized by sustained inflammation and/or ulcers along the lower digestive tract, and have complications such as colorectal cancer and inflammation in other organs. The current treatments for IBDs, which affect 0.3% of the global popula...

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Bibliographic Details
Main Authors: Zecheng Luo, Zihao Li, Zheng Liang, Lin Wang, Guanlin He, Dongdi Wang, Lei Shen, Zhengting Wang, Xiuying Ma, Funeng Geng, Haozhong Wang, Wenping Liu, Huijuan Liu, Baojie Li
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Biology
Subjects:
Berberine
Colitis
ISC
Wnt
Circadian rhythm
Stromal cell
Online Access:https://doi.org/10.1186/s12915-022-01492-z

Internet

https://doi.org/10.1186/s12915-022-01492-z

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