Evaluation of two inoculation routes of an adenovirus-mediated viral protein inhibitor in a Crimean-Congo hemorrhagic fever mouse model

Evaluation of two inoculation routes of an adenovirus-mediated viral protein inhibitor in a Crimean-Congo hemorrhagic fever mouse model

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne nairovirus with a wide geographic spread that can cause severe and lethal disease. No specific medical countermeasures are approved to combat this illness. The CCHFV L protein contains an ovarian tumor (OTU) domain with a cysteine proteas...

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Bibliographic Details
Main Authors: Florine E.M. Scholte, Jessica R. Spengler, Stephen R. Welch, Jessica R. Harmon, JoAnn D. Coleman-McCray, Katherine A. Davies, Scott D. Pegan, Joel M. Montgomery, Christina F. Spiropoulou, Éric Bergeron
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Virus Research
Subjects:
CCHFV
Nairovirus
Bunyavirus
Antiviral agents
Ubiquitin
Adenovirus/adenoviral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170224000911

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http://www.sciencedirect.com/science/article/pii/S0168170224000911

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