Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke

Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke

Abstract At the blood-brain barrier (BBB), laminin-α5 is predominantly synthesized by endothelial cells and mural cells. Endothelial laminin-α5 is dispensable for BBB maintenance under homeostatic conditions but inhibits inflammatory cell extravasation in pathological conditions. Whether mural cell-...

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Bibliographic Details
Main Authors: Abhijit Nirwane, Jessica Johnson, Benjamin Nguyen, Jeffrey H. Miner, Yao Yao
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Acta Neuropathologica Communications
Subjects:
Blood-brain barrier
Ischemic stroke
MCAO
Mural cells
Laminin
Online Access:http://link.springer.com/article/10.1186/s40478-019-0676-8

Internet

http://link.springer.com/article/10.1186/s40478-019-0676-8

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