Toxicokinetics of a humanized anti-cocaine monoclonal antibody in male and female rats and lack of cross-reactivity

Toxicokinetics of a humanized anti-cocaine monoclonal antibody in male and female rats and lack of cross-reactivity

ABSTRACTA humanized monoclonal antibody h2E2 designed to bind cocaine with high affinity, specificity, and a long half-life (~7 d in rats) is being developed as a treatment for cocaine use disorder. We report here a pharmacokinetic (PK) study of h2E2 using male and female rats conducted under a Good...

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Bibliographic Details
Main Authors: Rose P. Webster, Jordan A. Marckel, Andrew B. Norman
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Cocaine addiction
humanized
h2E2
monoclonal antibody
pharmacokinetics
toxicokinetics
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2023.2274222

Internet

https://www.tandfonline.com/doi/10.1080/21645515.2023.2274222

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