Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
The aim of this review is to provide an overview of green protocols for the organic synthesis of heterocycles via 1,3-dipolar cycloaddition. Particular attention has been devoted to the use of green solvents; reactions performed in ionic liquids, fluorinated solvents and water have been included. Al...
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Frontiers Media S.A.
2019-02-01
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Series: | Frontiers in Chemistry |
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Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2019.00095/full |
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author | Katia Martina Silvia Tagliapietra Valery V. Veselov Giancarlo Cravotto Giancarlo Cravotto |
author_facet | Katia Martina Silvia Tagliapietra Valery V. Veselov Giancarlo Cravotto Giancarlo Cravotto |
author_sort | Katia Martina |
collection | DOAJ |
description | The aim of this review is to provide an overview of green protocols for the organic synthesis of heterocycles via 1,3-dipolar cycloaddition. Particular attention has been devoted to the use of green solvents; reactions performed in ionic liquids, fluorinated solvents and water have been included. Also explored are several protocols that make use of catalyst-free reaction conditions, the use of microwave irradiation and activation by light exposure. Improvements over commonly used organic solvents will be underlined in order to highlight environmental protection aspects and enhancements in regio- and stereo-selectivity. |
first_indexed | 2024-12-11T08:54:59Z |
format | Article |
id | doaj.art-11dfa93387664c1d93d91d46849b45de |
institution | Directory Open Access Journal |
issn | 2296-2646 |
language | English |
last_indexed | 2024-12-11T08:54:59Z |
publishDate | 2019-02-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Chemistry |
spelling | doaj.art-11dfa93387664c1d93d91d46849b45de2022-12-22T01:13:55ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462019-02-01710.3389/fchem.2019.00095440545Green Protocols in Heterocycle Syntheses via 1,3-Dipolar CycloadditionsKatia Martina0Silvia Tagliapietra1Valery V. Veselov2Giancarlo Cravotto3Giancarlo Cravotto4Dipartimento di Scienza e Tecnologia del Farmaco and NIS, Centre for Nanostructured Interfaces and Surfaces, University of Turin, Turin, ItalyDipartimento di Scienza e Tecnologia del Farmaco and NIS, Centre for Nanostructured Interfaces and Surfaces, University of Turin, Turin, ItalyCenter of Bioanalytical Research and Molecular Design, Institute for Translational Medicine and Biotechnology, First Moscow State Medical University (Sechenov), Moscow, RussiaDipartimento di Scienza e Tecnologia del Farmaco and NIS, Centre for Nanostructured Interfaces and Surfaces, University of Turin, Turin, ItalyCenter of Bioanalytical Research and Molecular Design, Institute for Translational Medicine and Biotechnology, First Moscow State Medical University (Sechenov), Moscow, RussiaThe aim of this review is to provide an overview of green protocols for the organic synthesis of heterocycles via 1,3-dipolar cycloaddition. Particular attention has been devoted to the use of green solvents; reactions performed in ionic liquids, fluorinated solvents and water have been included. Also explored are several protocols that make use of catalyst-free reaction conditions, the use of microwave irradiation and activation by light exposure. Improvements over commonly used organic solvents will be underlined in order to highlight environmental protection aspects and enhancements in regio- and stereo-selectivity.https://www.frontiersin.org/article/10.3389/fchem.2019.00095/fullgreen chemistrydipolar cycloadditionsheterocyclesaqueous mediumIonic liquids |
spellingShingle | Katia Martina Silvia Tagliapietra Valery V. Veselov Giancarlo Cravotto Giancarlo Cravotto Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions Frontiers in Chemistry green chemistry dipolar cycloadditions heterocycles aqueous medium Ionic liquids |
title | Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions |
title_full | Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions |
title_fullStr | Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions |
title_full_unstemmed | Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions |
title_short | Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions |
title_sort | green protocols in heterocycle syntheses via 1 3 dipolar cycloadditions |
topic | green chemistry dipolar cycloadditions heterocycles aqueous medium Ionic liquids |
url | https://www.frontiersin.org/article/10.3389/fchem.2019.00095/full |
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