Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions

The aim of this review is to provide an overview of green protocols for the organic synthesis of heterocycles via 1,3-dipolar cycloaddition. Particular attention has been devoted to the use of green solvents; reactions performed in ionic liquids, fluorinated solvents and water have been included. Al...

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Main Authors: Katia Martina, Silvia Tagliapietra, Valery V. Veselov, Giancarlo Cravotto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00095/full
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author Katia Martina
Silvia Tagliapietra
Valery V. Veselov
Giancarlo Cravotto
Giancarlo Cravotto
author_facet Katia Martina
Silvia Tagliapietra
Valery V. Veselov
Giancarlo Cravotto
Giancarlo Cravotto
author_sort Katia Martina
collection DOAJ
description The aim of this review is to provide an overview of green protocols for the organic synthesis of heterocycles via 1,3-dipolar cycloaddition. Particular attention has been devoted to the use of green solvents; reactions performed in ionic liquids, fluorinated solvents and water have been included. Also explored are several protocols that make use of catalyst-free reaction conditions, the use of microwave irradiation and activation by light exposure. Improvements over commonly used organic solvents will be underlined in order to highlight environmental protection aspects and enhancements in regio- and stereo-selectivity.
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spelling doaj.art-11dfa93387664c1d93d91d46849b45de2022-12-22T01:13:55ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462019-02-01710.3389/fchem.2019.00095440545Green Protocols in Heterocycle Syntheses via 1,3-Dipolar CycloadditionsKatia Martina0Silvia Tagliapietra1Valery V. Veselov2Giancarlo Cravotto3Giancarlo Cravotto4Dipartimento di Scienza e Tecnologia del Farmaco and NIS, Centre for Nanostructured Interfaces and Surfaces, University of Turin, Turin, ItalyDipartimento di Scienza e Tecnologia del Farmaco and NIS, Centre for Nanostructured Interfaces and Surfaces, University of Turin, Turin, ItalyCenter of Bioanalytical Research and Molecular Design, Institute for Translational Medicine and Biotechnology, First Moscow State Medical University (Sechenov), Moscow, RussiaDipartimento di Scienza e Tecnologia del Farmaco and NIS, Centre for Nanostructured Interfaces and Surfaces, University of Turin, Turin, ItalyCenter of Bioanalytical Research and Molecular Design, Institute for Translational Medicine and Biotechnology, First Moscow State Medical University (Sechenov), Moscow, RussiaThe aim of this review is to provide an overview of green protocols for the organic synthesis of heterocycles via 1,3-dipolar cycloaddition. Particular attention has been devoted to the use of green solvents; reactions performed in ionic liquids, fluorinated solvents and water have been included. Also explored are several protocols that make use of catalyst-free reaction conditions, the use of microwave irradiation and activation by light exposure. Improvements over commonly used organic solvents will be underlined in order to highlight environmental protection aspects and enhancements in regio- and stereo-selectivity.https://www.frontiersin.org/article/10.3389/fchem.2019.00095/fullgreen chemistrydipolar cycloadditionsheterocyclesaqueous mediumIonic liquids
spellingShingle Katia Martina
Silvia Tagliapietra
Valery V. Veselov
Giancarlo Cravotto
Giancarlo Cravotto
Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
Frontiers in Chemistry
green chemistry
dipolar cycloadditions
heterocycles
aqueous medium
Ionic liquids
title Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
title_full Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
title_fullStr Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
title_full_unstemmed Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
title_short Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
title_sort green protocols in heterocycle syntheses via 1 3 dipolar cycloadditions
topic green chemistry
dipolar cycloadditions
heterocycles
aqueous medium
Ionic liquids
url https://www.frontiersin.org/article/10.3389/fchem.2019.00095/full
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AT silviatagliapietra greenprotocolsinheterocyclesynthesesvia13dipolarcycloadditions
AT valeryvveselov greenprotocolsinheterocyclesynthesesvia13dipolarcycloadditions
AT giancarlocravotto greenprotocolsinheterocyclesynthesesvia13dipolarcycloadditions
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