Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer.

Buruli ulcer is an emerging chronic infectious skin disease caused by Mycobacterium ulcerans. Mycolactone, an exotoxin produced by the bacterium, is the only identified virulence factor so far, but the functions of this toxin and the mechanisms of disease progression remain unclear. By interfering S...

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Bibliographic Details
Main Authors: Toshihiko Suzuki, Kotchakorn Boonyaleka, Tokuju Okano, Tamako Iida, Mitsunori Yoshida, Hanako Fukano, Yoshihiko Hoshino, Yoichiro Iwakura, Anthony S Ablordey, Hiroshi Ashida
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-11-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011747&type=printable