Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue

Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue

Each heartbeat is initiated by specialized pacemaker cells operating within the sinoatrial node (SAN). While individual cells within SAN tissue exhibit substantial heterogeneity of their electrophysiological parameters and Ca cycling, the role of this heterogeneity for cardiac pacemaker function rem...

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Bibliographic Details
Main Authors: Alexander V. Maltsev, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Physiology
Subjects:
sinoatrial node
coupled-clock pacemaker system
numerical modeling
calcium release
sarcoplasmic reticulum
cardiac arrhythmia
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.845634/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.845634/full

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