RAPTOR promotes colorectal cancer proliferation by inducing mTORC1 and upregulating ribosome assembly factor URB1

RAPTOR promotes colorectal cancer proliferation by inducing mTORC1 and upregulating ribosome assembly factor URB1

Abstract Mammalian target of rapamycin complex 1 (mTORC1) is evolutionally conserved and frequently activated in various tumors, including colorectal cancer (CRC). It has been reported that the ribosome assembly factor Urb1 acts downstream of mTORC1/raptor signaling and contributes to digestive orga...

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Bibliographic Details
Main Authors: Tao Wang, Wei‐Sheng Zhang, Zheng‐Xia Wang, Zhi‐Wei Wu, Bin‐Bin Du, Lai‐Yuan Li, Yi‐Feng Chen, Xiong‐Fei Yang, Xiang‐Yong Hao, Tian‐Kang Guo
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Cancer Medicine
Subjects:
colorectal cancer
cyclinA2
mTORC1
proliferation
RAPTOR
URB1
Online Access:https://doi.org/10.1002/cam4.2810

Internet

https://doi.org/10.1002/cam4.2810

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