Treatment of human cardiac fibroblasts with the protein arginine deiminase inhibitor BB-Cl-amidine activates the Nrf2/HO-1 signaling pathway

Treatment of human cardiac fibroblasts with the protein arginine deiminase inhibitor BB-Cl-amidine activates the Nrf2/HO-1 signaling pathway

Background: Cardiac fibrosis contributes to end-stage extracellular matrix remodeling and heart failure (HF). Cardiac fibroblasts (CFs) differentiate into myofibroblasts (myoFbs) to preserve the structural integrity of the heart; however, the molecular mechanisms regulating CF transdifferentiation r...

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Bibliographic Details
Main Authors: Aneta Stachowicz, Alia Sadiq, Brian Walker, Niveda Sundararaman, Justyna Fert-Bober
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Citrullination
Protein arginine deiminase
Proteomics
Cardiac fibrosis
Posttranslational modification
Heme oxygenase 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223012416

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http://www.sciencedirect.com/science/article/pii/S0753332223012416

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