Exploring Amantadine Derivatives as Urease Inhibitors: Molecular Docking and Structure–Activity Relationship (SAR) Studies

Exploring Amantadine Derivatives as Urease Inhibitors: Molecular Docking and Structure–Activity Relationship (SAR) Studies

This article describes the design and synthesis of a series of novel amantadine-thiourea conjugates (<b>3a</b>–<b>j</b>) as Jack bean urease inhibitors. The synthesized hybrids were assayed for their in vitro urease inhibition. Accordingly, <i>N</i>-(adamantan-1-y...

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Bibliographic Details
Main Authors: Atteeque Ahmed, Aamer Saeed, Omar M. Ali, Zeinhom M. El-Bahy, Pervaiz Ali Channar, Asma Khurshid, Arfa Tehzeeb, Zaman Ashraf, Hussain Raza, Anwar Ul-Hamid, Mubashir Hassan
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
acyl/aroyl thioureas
urease inhibitors
synthesis
enzyme inhibitory kinetics
molecular docking
Online Access:https://www.mdpi.com/1420-3049/26/23/7150

Internet

https://www.mdpi.com/1420-3049/26/23/7150

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