Cytoplasmic TDP43 Binds microRNAs: New Disease Targets in Amyotrophic Lateral Sclerosis

Cytoplasmic TDP43 Binds microRNAs: New Disease Targets in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, and incurable neurodegenerative disease. Recent studies suggest that dysregulation of gene expression by microRNAs (miRNAs) may play an important role in ALS pathogenesis. The reversible nature of this dysregulation makes miRNAs attractive...

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Bibliographic Details
Main Authors: Ximena Paez-Colasante, Claudia Figueroa-Romero, Amy E. Rumora, Junguk Hur, Faye E. Mendelson, John M. Hayes, Carey Backus, Ghislaine F. Taubman, Laurie Heinicke, Nils G. Walter, Sami J. Barmada, Stacey A. Sakowski, Eva L. Feldman
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
amyotrophic lateral sclerosis
trans-activation response element DNA/RNA-binding protein of 43 kDa (TDP43)
microRNAs
cytoplasmic aggregates
profiling
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00117/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00117/full

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